Pharmacokinetic analyses of sodium 2,2 dimethyl butyrate in baboons.

Single oral or intravenous doses were administered and concentrations of the compound were analyzed in plasma samples collected sequentially between 15 minutes and 8 to 24 hours after the administered dose. (A) Comparison of plasma levels after the administration of 100 mg/kg doses of sodium 2,2 dimethyl butyrate given intravenously (○) and orally (●). By either route of administration, the compound was detected above the targeted concentration of 100 μM for 8 hours. (B) Repeat-dose pharmacokinetic analyses of sodium 2,2 dimethyl butyrate after the administration of 150 mg/kg in baboon 2298 administered orally on 3 separate occasions with 2 to 3 days between each dose. Plasma levels are designated by open circles after the first dose, closed circles after the second dose, and open squares after the third dose. Plasma concentrations remained above the targeted plasma level (100 μM) for more than 12 hours. (C) Plasma concentrations of sodium 2,2 dimethyl butyrate after the administration of single doses in 3 baboons. Plasma levels were detected after single doses of 2,2 dimethyl butyrate at 40 mg/kg intravenously in baboon 1197 (○), 75 mg/kg orally in baboon 5014 (▵), 100 mg/kg orally in baboon 5014 (▴), 100 mg/kg orally in baboon 1197 (●), and 100 mg/kg orally in baboon 3397 (▪). Levels remained above the targeted concentration (100 μM) for 6 to 8 hours.