Pharmacokinetic analyses of sodium α methylhydrocinnamate in baboons.

Single oral or intravenous doses were administered, and concentrations of the compound were analyzed in plasma samples collected sequentially between 15 minutes and 8 to 24 hours after the administered dose. (A) Comparison of plasma concentrations of sodium α methylhydrocinnamate after a single intravenous dose (▪) and a single oral dose (○) of 113 mg/kg in baboon 1997. The compound was detected in the plasma at, or above, the targeted concentration of 100 μM for 6 to 8 hours. (B) Repeat-dose pharmacokinetics of one oral dose (200 mg/kg) of sodium α methylhydrocinnamate administered on 4 separate days over 1 month to baboon 1997. Concentrations in the plasma after the single oral doses were similar and resulted in plasma concentrations above the targeted level (100 μM) for 6 hours. (C) Plasma levels of sodium α methylhydrocinnamate in baboons after the administration of single doses of 50 mg/kg orally (○), 100 mg/kg orally (●), 200 mg/kg orally (■), and 500 mg/kg orally (▪).