High degree of homology in the D1 domain across species.

The VWFpp of human, porcine, bovine, canine, and murine VWF have been aligned. Shown in this Figure is a 60-aa span of the D1 domain for 5 species and the Tyr87Ser mutation in human sequence. Murine VWF has been reported for only a small portion of the D1 domain, shown here from residues 74 through 120. Only differences are shown, with · depicting a perfect homology match. Between the 5 species' VWFpp's, there is a very strong homology throughout this region in the D1 domain of perfectly conserved and well-conserved amino acids (86% to 95%), indicating that the Tyr87Ser mutation may alter the configuration of the region.