Fig. 1.
Fig. 1. Sequence of hIL-17E, protein alignment with IL-17 cytokine family members, and human tissue expression. / (A) Nucleotide sequence and predicted protein sequence of hIL-17E molecule (GenBank accession number AF461739). The 3′ untranslated sequence upstream with start Met is indicated in red. Underlined sequence is the predicted signal sequence. (B) Alignment of hIL-17 protein family members with hIL-17E molecule reported herein (indicated in italics). FASTA searches of the Swiss Protein Database revealed hIL-17E conserved cysteine residues (indicated in red; complete conservation among all members indicated by red asterisk) and approximately 25% to 35% homology with all other IL-17 proteins. Other important conserved residues are highlighted in green. Residues conserved with IL-17B and IL-17C are indicated in bold. (C) IL-17E expression in human tissues (RNA purchased from Clontech) byTaqman quantitative analysis.

Sequence of hIL-17E, protein alignment with IL-17 cytokine family members, and human tissue expression.

(A) Nucleotide sequence and predicted protein sequence of hIL-17E molecule (GenBank accession number AF461739). The 3′ untranslated sequence upstream with start Met is indicated in red. Underlined sequence is the predicted signal sequence. (B) Alignment of hIL-17 protein family members with hIL-17E molecule reported herein (indicated in italics). FASTA searches of the Swiss Protein Database revealed hIL-17E conserved cysteine residues (indicated in red; complete conservation among all members indicated by red asterisk) and approximately 25% to 35% homology with all other IL-17 proteins. Other important conserved residues are highlighted in green. Residues conserved with IL-17B and IL-17C are indicated in bold. (C) IL-17E expression in human tissues (RNA purchased from Clontech) byTaqman quantitative analysis.

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