IL-7 recipients show increased histologic evidence of GVHD
. Histologic assessment of the 8 tissues listed in “Materials and methods” was made and rated as absent (0), mild (1+), moderate (2+), or severe (3+). The total score for each animal was tabulated as the histologic index, and the mean index of 5 to 7 animals in each group is shown. (A) All tissues examined combined for each cell dose. Statistically significant differences exist at 1 × 106(P = .0002) and 10 × 106 (P = .04) and syngeneic (P = .04). (B) Mean histologic index for individual tissues in the group of animals that received 1 × 106 LN cells with or without IL-7. Significant differences (P < .05) are found between IL-7 and control groups for liver, colon, and mesentery. Histologic analysis was performed in 2 separate experiments with similar results. Bars represent SEM.
