IL-7 increases weight loss and lethality in a T-cell–dependent manner following allogeneic BMT.
B6C3F1 hosts were lethally irradiated and received TCD C57BL/6 BM and graded numbers of LN cells (n=8/group). IL-7–treated groups (dotted lines) received 5 μg/d rhIL-7 intraperitoneally from day 1 to day 28 after BMT. (A) Animals were weighed 3 times weekly. Statistically significant differences are observed in IL-7– versus sham-treated groups at each dose level (1 × 106, P < .01; 5 × 106, P < .001; 7.5 × 106,P < .01). (B) Survival plots are shown. A significant increase in mortality is observed in rhIL-7 recipients that received 7.5 × 106 LN cells (P = .009) compared with sham. The P value for 5 × 106 is .06. This experiment was performed twice with similar results.
