Representative histological appearance of glomerular lesions of kidneys from 48-week-old chimeric mice.

BALB/c (panel A); BALB/c→BXSB (panel B); BALB/c+BXSB→ BXSB (panel C); BXSB→BXSB (panel D); BALB/c+BXSB→BALB/c (panel E). Note the marked difference in the size and the mesangial-glomerular cellularities of glomeruli between syngeneic chimeras and mixed chimeras. The tissues were stained with PAS reagent (original magnification, × 100).