Fig. 6.
CCL4-mediated inhibition of CXCL12-induced chemotaxis of bone marrow B cells: specificity controls for CCR5.
The degree of inhibition is expressed as the percent migration of CCL4-treated cells toward CXCL12 (second bar for each B-cell subset), compared with the migration of cells pretreated with medium alone (first bar for each B-cell subset). The third bar for each B-cell subset indicates migration of the cells pretreated with 2D7-neutralizing anti-CCR5 antibody; the fourth bar indicates migration of the cells pretreated with IgG2a isotype control antibody; and the fifth bar indicates migration of the cells pretreated with the nonneutralizing anti-CCR5 antibody (clone 45529). Migration toward CXCL12 of untreated cells was considered 100%.
