Histologic observation of the lung after AMI.

Lung histology (HE stain) demonstrating pulmonary edema in α2-AP^+/+ (B) mouse and α2-AP^−/− (A,C,D) mice. Note, (A) an alveolar part in normal lung in α2-AP^−/− mouse (×160); (B) the alveolar tissue with slight stromal thickness because of congestion in α2-AP^+/+ mouse with coronary ligation (×160); (C) pulmonary edema can be observed in the alveolar space with a few erythrocytes, which means diapedesis through a wall of vessel in α2-AP^−/− mouse with coronary ligation (×200); (D,E) spotty alveolar hemorrhages can be seen in α2-AP^−/− mouse with coronary ligation (×160 or × 400). Heart failure cells, which are phagocytes of erythrocytes and hemosiderins, in the alveolar space (arrowheads in D).