The effect of IL-11 on the formation of TRAP⁺ MNCs.

Cocultures of murine calvaria and bone marrow cells were maintained in the absence or presence of increasing doses of IL-11. Nine days later the cells were stained for TRAPase activity and the number of multinucleated TRAP⁺ cells per well determined as described in “Materials and methods.” Data are expressed as mean ± SEM. *P < .01 when compared with the number of TRAP⁺ cells counted in the absence of IL-11.