Fig. 11.
Effect of anti-CD14 and compstatin onE coli–induced cytokine formation.
IL-6 and IL-8 (median and 25-75 percentile of 5 experiments) and IL-10 (median and range of 3 experiments for higher dose; 1 experiment with lower dose) were measured in plasma after incubation of whole blood withE coli for 2 and 18 hours, respectively. The effect of anti-CD14 (clone 18D11, F(ab′)2 fragments, 0.7 μM) (open columns) and compstatin (50 μM) (hatched columns) is presented as percent inhibition of cytokine formation compared with control peptide or control F(ab′)2 antibody.
