Fig. 7.
![Fig. 7. Effect of the C5aR antagonist AcF[OPdChaWR] on. / E coli–induced oxidative burst in granulocytes.The left panel shows dose-response effect of the C5aR antagonist using 1 × 108 E coli per milliliter (1 representative of 5 experiments is shown). The right panel shows the effect of 2 μM C5aR antagonist on E coli–induced oxidative burst by reducing the concentration ofE coli (median and range of triplicate). The oxidative burst is given as median fluorescence intensity (MFI). ▵ indicates baseline value (T0); ▴, whole blood incubated 10 minutes withE coli (1 × 108 bacteria per milliliter); ●, E coli plus C5aR antagonist; ○, E coli plus control peptide; and ■, E coli plus PBS.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/100/5/10.1182_blood.v100.5.1869.h81702001869_1869_1877/3/h81723034007.jpeg?Expires=1724268273&Signature=sPKDxsbKvyAELAXazjaEykjbGY0-wjx4GHYQHky9~uAeNtSlXff83a99lcezqpHu4wSsrMob~33FTuFH8a~Eje2VUcd8mAcxZhnri5dKhrYpS~hPleGQ09S1g5coaKSapSrLsa-W7xNoYFmY1WVqf41bIgXcHPQkh6QcMX7RPaXqY1PqdYsV5cfxlpbKBXuUurMZZzMBGFzu9xIJxyvFKvMl7vF-r6W3RXxWrZznMjIYG17Is6U1z3SNbTlr17YBgcPQTEE-qmsZM3cm7i1NvlOxKaUpNed8ZNF28tSdKYn3tiqrMP0ED7S1I1CEJhoGEoCTantL2S7M1SIUjG-mTQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effect of the C5aR antagonist AcF[OPdChaWR] on
E coli–induced oxidative burst in granulocytes.The left panel shows dose-response effect of the C5aR antagonist using 1 × 108E coli per milliliter (1 representative of 5 experiments is shown). The right panel shows the effect of 2 μM C5aR antagonist on E coli–induced oxidative burst by reducing the concentration ofE coli (median and range of triplicate). The oxidative burst is given as median fluorescence intensity (MFI). ▵ indicates baseline value (T0); ▴, whole blood incubated 10 minutes withE coli (1 × 108 bacteria per milliliter); ●, E coli plus C5aR antagonist; ○, E coli plus control peptide; and ■, E coli plus PBS.
