Effect of lepirudin and heparin on spontaneous complement activation in human serum.

Serum was incubated for 60 minutes at 37°C, and complement activation was detected by assay of the terminal sC5b-9 complex (TCC). Each symbol represents results from 1 of 6 healthy blood donors. T0 indicates baseline sample. Lepirudin, left panel; heparin, right panel.