Next-generation sequencing and cytogenetics studies of clonal hematopoiesis in acquired AA. Advances in next-generation genome analysis technology, including single nucleotide polymorphism arrays (SNP-A), targeted next-generation sequencing (NGS), whole-exome sequencing (WES), and NGS-based HLA typing, have generated several waves of studies of clonal evolution in AA, uncovering the near-ubiquitous presence of clonal hematopoiesis in the recovering marrow of AA patients.