Cumulative incidence of relapse in patients with B-lineage ALL according to MRD distribution at the end of remission induction therapy.

Dashed lines indicate cumulative incidence of relapse of patients with 0.01% or more leukemic cells in bone marrow (MRD+) and of patients with less than 0.01% leukemic cells (MRD−). Solid lines indicate the cumulative incidence of relapse of MRD+ patients with MRD confined to the bone marrow (BM) or detectable MRD in the peripheral blood (PB).