Distribution of MRD in bone marrow and peripheral blood of patients with T-lineage ALL and B-lineage ALL.

Values represent the percentage of residual disease determined by flow cytometry in paired bone marrow and peripheral blood samples. Symbols indicate samples collected on days 19 and 26 of remission induction therapy (○), at the end of remission induction (day 46; ▵), and during weeks 14, 32, 56, or 120 of continuation chemotherapy (■). In the lower left quadrant, numbers of MRD-negative paired samples collected at the various treatment intervals are shown.