American Society of Hematology

Fig. 4.

$Fig. 4. Correlations between the CD4+ T-cell response to CMV pp65 (by CFC) and measures of the CD8+ T-cell response to CMV. / (A) There is a significant positive correlation between the magnitude of the CD4+ pp65-specific T-cell response (by CFC) and the magnitude of the CMV-specific CD8+ T-cell response by HLA-peptide tetramer staining (p = .002, Spearman) (B) There is a significant positive correlation between the magnitude of the CD4+ pp65-specific T-cell response (by CFC) and the magnitude of the CMV-specific CD8+ T-cell response by CFC following pp65 peptide stimulation (p = .0008, Spearman). (C) There is no significant correlation between pp65-specific CD4+ T cells (by CFC) and the functional fraction of tetramer-staining CD8+ T cells (by assessment of TNF-α production in tetramer-positive cells following cognate peptide stimulation); p = .6, Spearman.$

Correlations between the CD4⁺ T-cell response to CMV pp65 (by CFC) and measures of the CD8⁺ T-cell response to CMV.

(A) There is a significant positive correlation between the magnitude of the CD4⁺ pp65-specific T-cell response (by CFC) and the magnitude of the CMV-specific CD8⁺ T-cell response by HLA-peptide tetramer staining (p = .002, Spearman) (B) There is a significant positive correlation between the magnitude of the CD4⁺ pp65-specific T-cell response (by CFC) and the magnitude of the CMV-specific CD8⁺ T-cell response by CFC following pp65 peptide stimulation (p = .0008, Spearman). (C) There is no significant correlation between pp65-specific CD4⁺ T cells (by CFC) and the functional fraction of tetramer-staining CD8⁺ T cells (by assessment of TNF-α production in tetramer-positive cells following cognate peptide stimulation); p = .6, Spearman.

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