Eto deletion in one AML1-ETO leukemia case.

(A) AML1-ETO RT-PCR disclosed an abnormal band that was smaller than the typical specific product. M indicates molecular weight marker; C+, positive control; C−, blank sample; and P, patient. (B) Direct sequencing of the abnormal PCR product revealed a 50-bp ETO deletion. (C) Diagram representation of the 50-bp deletion. Only 7 residues of the ETO sequence are conserved in this abnormal chimeric product.