Declining of INR values during the 5 days of warfarin suspension before surgery/intervention. Different colors denote different warfarin indications. The orange line show the mean INR values for all indications. Warfarin was resumed at a 50% increased maintenance dose for 2 days starting the first or second day after surgery/intervention. Therapeutic INR values were usually reached after 1 week. AF, atrial fibrillation; VTE, venous thrombosis.