Signaling through the CARD9-containing caspase recruitment domain–B-cell lymphoma 10–mucosa-associated lymphoid tissue lymphoma–translocation gene 1 complex. In myeloid cells, activation of C-type lectin receptors for Dectin1 and Dectin2, as well as Toll-like receptors, leads to phosphorylation of the CARD9 protein and formation of a complex with B-cell lymphoma 10 and mucosa-associated lymphoid tissue lymphoma translocation gene 1. This CARD9-containing caspase recruitment domain–B-cell lymphoma 10–mucosa-associated lymphoid tissue lymphoma–translocation gene 1 complex is necessary to activate NF-ΚΒ and pro-inflammatory gene expression downstream of C-type lectin receptors. From Pérez de Diego et al,⁵⁴  with permission.