Fig. 6.
Reduced T-cell receptor–mediated proliferation in
Nf1−/− splenic T cells. Splenocytes (A) or purified T cells (2 × 105/well) (B) were isolated and activated with plate-bound anti-CD3 mAb or anti-CD3 mAb plus IL-2. Proliferation was measured by thymidine incorporation assay. Bars denote the mean thymidine incorporation (cpm ± SEM) of a representative experiment performed in replicates of 6. ** P < .01 Nf1−/− versus WT.
