Fig. 3. Erythrocyte pausing on neutrophils and dependence on neutrophil activation state. / (A) One of many short-lived pausing events observed as washed erythrocytes were perfused over fibrinogen-adherent, fMLP-activated neutrophils at a wall shear rate of 50 s−1. Following capture, membrane tethering, and a pause for 800 milliseconds, the red cell was released by the neutrophil. Visualization of firmly adhered erythrocytes on untreated neutrophils (B) or fMLP-stimulated neutrophils (C) demonstrated the dependence of RBC adhesion on neutrophil activation after 5 minutes at γw = 50 s−1. Identical results were obtained in 3 separate experiments, each conducted with an individual donor. Flow was from right to left.
Fig. 3.

Erythrocyte pausing on neutrophils and dependence on neutrophil activation state.

(A) One of many short-lived pausing events observed as washed erythrocytes were perfused over fibrinogen-adherent, fMLP-activated neutrophils at a wall shear rate of 50 s−1. Following capture, membrane tethering, and a pause for 800 milliseconds, the red cell was released by the neutrophil. Visualization of firmly adhered erythrocytes on untreated neutrophils (B) or fMLP-stimulated neutrophils (C) demonstrated the dependence of RBC adhesion on neutrophil activation after 5 minutes at γw = 50 s−1. Identical results were obtained in 3 separate experiments, each conducted with an individual donor. Flow was from right to left.

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