Interspecies comparison of orthologous genes expressed by human and mouse MCs.

The expression levels of 287 pairs of orthologous genes were compared. The horizontal direction stands for the expression levels of human genes and the vertical direction represents those of mouse genes. Each point represents the average of 2 (human) or 3 (mouse) independent experiments shown in Tables 1 and 2. The expression levels of I-309 (CCL1), MCP-1 (CCL2), MIP-1α (CCL3), MIP-1β (CCL4), and 4-1BB (CD137) genes in resting MCs (panel A) were increased in activated MCs (panel B), while those of tryptase and major basic protein (MBP) remained at similar levels. The expression levels were normalized into a percentage of the average of 6 housekeeping genes (♦). The oblique broken lines indicate a 10-fold difference.