Heparin inhibits the flow adhesion of sickle erythrocytes to immobilized P-selectin in vitro.

The number of sickle cells adhering to immobilized protein and the rolling velocities of the adhering cells were examined. In 3 experiments the rolling adhesion of sickle cells to immobilized recombinant P-selectin was examined in the presence and absence of unfractionated heparin. Statistically significant differences compared with immobilized recombinant P-selectin (†) are indicated.