Sickle cells adhere to immobilized P-selectin under flow conditions in vitro.

The number of sickle cells adhering to immobilized protein and the rolling velocities of the adhering cells were examined. In 5 experiments the rolling adhesion of sickle cells to BSA, immobilized recombinant Siglec, or immobilized recombinant P-selectin were examined. Statistically significant differences compared to immobilized BSA (*) and to immobilized recombinant Siglec (†) are indicated.