Serum IGF-1 and IGFBP-3 levels in patients with MM and healthy controls.

(A) Serum IGF-1 levels in 127 patients with MM (17.8 ± 7.7 nM) and 42 healthy controls (17.3 ± 5.6 nM). This difference was not significant. Horizontal lines indicate mean levels. (B) Serum IGFBP-3 levels in 127 patients with multiple myeloma (1.6 ± 0.73 μg/mL) and 42 healthy controls (2.2 ± 0.42 μmL). This difference was highly significant (P < .001). Horizontal lines indicate mean levels.