Signaling pathways subverted in T-cell oncogenesis. A subset of the TCR, costimulatory, and interleukin receptor pathways showing the redundancy and complexity of signaling. Recurrently mutated receptors and signaling pathway components are depicted with bold outlines. DAG, diacylglycerol; GTP, guanine nucleotide triphosphate; IL-6, interleukin-6; IP₃, inositol 3-phosphate; MHC, major histocompatibility complex; mTOR, mammalian target of rapamycin; P, phosphorylation; PTPN, protein tyrosine phosphatase nonreceptor. Reprinted from Van Arnam et al.²¹