Factors of independent prognostic effect on outcome in multivariable analysis of OS in the CLL1 trial of the GCLLSG for early stage (Binet A) CLL (n = 534)
The following variables were included as potential factors: age (>60/≤60), sex, Rai stage (≥1/0), Eastern Cooperative Oncology Group status (≥1/0), comorbidities (≥1/0), white blood cell count (>20/≤20 × 109/L), absolute lymphocyte count (>20/≤20 × 109/L), hemoglobin level (male <14 and female <12 g/dL, male ≥14 and female ≥12 g/dL), platelet count (<150/≥150 × 109/L), serum lactate dehydrogenase level (>250/≤250 U/L), serum creatinine (male >1.2 mg/dL and female >1.0 mg/dL, male ≤1.2 and female ≤1.0 mg/dL), β2-MG level (≥3.5/<3.5 mg/L), TK level (≥7/<7 U/L and ≥10/<10 U/L), involvement of lymph node sites (cervical, axillary, inguinal lymph nodes), hepato- and splenomegaly, genomic aberrations as single variables (17p−, 11q−, +12, 13q−, normal), IGHV status, and V3-21 usage.
