Pictorial representation of the 3 different degrees of VWD severity according to levels of VWF and FVIII activities: severe, moderate, and mild VWD. In the upper part of the pyramid, “severe VWD” cases (VWD3, VWD2A, and VWD1) are included with levels of VWF:RCo <10 U/dL and/or FVIII:C <20 U/dL; the “moderate VWD” cases (VWD2B, VWD2M, VWD2N, and VWD1) with levels of VWF:RCo 10-30 U/dL and/or FVIII:C 20-40 U/dL; and the “mild VWF” (VWF:RCo 30-50 U/dL and/or FVIII:C 40-60 U/dL) are described in the middle portion and in the base of the pyramid.