Restricted cubic spline curve showing the age- and sex-adjusted relationship between VWF:RCo plasma levels and BS in all RENAWI-2 patients with VWD. Dotted lines represent 95% confidence intervals. A plateau was found at a mean BS value of 3.5 (dashed horizontal line) that was reached for VWF:RCo levels >30 IU/dL. More detailed information is provided in Federici et al.³¹