Human γ-globin gene locus on chromosome 11 showing the ontology of expression of the embryonic, fetal, and adult globin genes controlled by locus control regions. In adult life, the transcription of γ-globin is highly repressed. Some of the major transcription factors involved in the repression of γ-globin are highlighted. Reprinted with permission from Chandrakasan and Malik, 2014.²⁵