Possible treatment sequencing approaches in CML. At least 48 unique sequences can be identified. Not all options might be available in all parts of the world or they may have different indications. Stem cell transplant, investigational options, combination therapy, and others are not included for simplicity; including these options increases the number of sequence options available. B, bosutinib; D, dasatinib; I, imatinib; N, nilotinib; O, omacetaxine; P, ponatinib.