Mechanisms in DIC. Systemic activation of hemostatic processes leads to thrombin generation and its consequences, which include intravascular fibrin deposition, depletion of hemostatic factors, fibrinolytic pathway involvement, and PAR-mediated cell signaling responses. As a result, there may be thrombosis of small vessels contributing to organ failure, severe bleeding, capillary leakage, and edema. FDP indicates fibrin-degradatory products.