Table 1.

Retrospective studies assessing the prognostic relevance of KIT mutations in t(8;21) and inv(16) AML

Retrospective studies assessing the prognostic relevance of KIT mutations in t(8;21) and inv(16) AML

NR indicates not reported; RR, relapse rate; MVA, multivariable analysis; HR, hazard ratio; PFS, progression-free survival; CIR, cumulative incidence of relapse; and RI, relapse incidence.

aNumber of patients with mutated KIT/total patients studied.

bAge range and median are provided for all patients in the study including 113 patients with t(8;21) and 90 patients with inv(16).

cMedian follow-up is provided for all patients in the study including 82 patients with t(8;21) and 39 with inv(16).

dMedian follow-up is provided for all patients in the study including 82 patients with t(8;21) and 94 with inv(16).

eOutcome analyses were performed on a subset of 60 patients in whom KIT mutation status was assessed.

fAge range and median are provided for all patients in the study including 56 patients with t(8;21) and 47 with inv(16).

g Median follow-up is provided for all patients in the study including 56 patients with t(8;21) and 47 with inv(16).

hThe KIT gene comprises 21 exons.

iMedian follow-up for OS.

jOutcome analyses based on 36 patients who received intensive chemotherapy; all 36 patients were below the age of 60 years and 19 of 36 (53%) patients carried a KIT mutation.

kOutcome analyses were performed on subset of 57 patients in whom KIT mutation status was assessed.

lMean age is provided instead of median age.

mOutcome analyses based on 42 patients who received intensive chemotherapy; all 42 patients were below the age of 60 years and 13 of 42 (31%) patients carried a KIT mutation.

nAnalysis based on 5 patients with KIT exon 8 mutations.

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