Novel risk assignment schemes. (A) Risk assignment based on FISH and ISS. ISS 1 includes patients with albumin ≥3.5 g/dL and B2M <3.5 mg/L; ISS III includes patients with B2M >5.5 mg/L; and ISS II includes any patient who is not ISS I or III. HR-FISH was defined as del(17p) and/or t(4;14). Data are derived from an analysis of 2642 patients with FISH from the original cohort of 10 750 patients.^3,12  No patients received lenalidomide or bortezomib as induction. (B) The R-ISS. HR-FISH was del(17p) and/or t(4;14). Data are generated from 3060 patients from 11 international trials conducted from 2005 to 2012 that were pooled and analyzed by the IMWG.¹⁴  Abl, abnormal; Int, intermediate; Nml, normal.