Meta-analysis of the Papaemmanuil et al²³  2016 chromatin-spliceosome subgroup. Kaplan-Meier curves for overall survival are shown for 3 subsets of patients that classify with the chromatin-spliceosome group (n = 299) substratified according to ELN 2017 risk (favorable, n = 8; intermediate, n = 113; and adverse, n = 178). As shown by the graphic, the 113 patients who are classified as intermediate risk have equally adverse outcomes as the patients classified as adverse risk according to RUNX1, ASXL1, or FLT3^ITD high or chromosomal aneuploidies.