aPTT indicates activated partial thromboplastin time; CrCl, creatinine clearance; cryo, cryoprecipitate; CVVHD, continuous venovenous hemodialysis; CVVHDF, continuous venovenous hemodiafiltration; DC, dabigatran concentration; eGFR, estimated glomerular filtration rate; FFP, fresh frozen plasma; HD, hemodialysis; INR, international normalized ratio; PCC, prothrombin complex concentrate; pRBCs, packed RBCs; PT, prothrombin time; rFVIIa, recombinant factor VIIa; TKA, total knee arthroplasty; and TT, thrombin time.

*Prophylactic dabigatran dose of 220 mg once daily.