Figure 2.
Manufacture of CAR-modified T cells. Peripheral blood mononuclear cells collected by leukapheresis are expanded ex vivo and transduced to express the CAR molecule before infusion into the patient. In this example, magnetic beads coated with antibodies to CD3 and CD28 are used for ex vivo expansion.40 (Image used with permission from Novartis Pharmaceuticals. Copyright 2014, Novartis Corporation.)
