Figure 1.
CAR structure. CAR molecules link an extracellular scFv to intracellular signaling domains. The intracellular component includes the CD3ζ intracellular signaling domain of the TCR either alone (first-generation) or in combination with 1 (second-generation) or 2 (third-generation) costimulatory domains. (Image courtesy of M. Maus.41 )