Typical smear of blood and marrow aspirate in CML, aCML, and CNL. (A) CML peripheral blood smear. Morphologically unremarkable neutrophils with frequent immature granulocytes, including a disproportionally high percentage of myelocytes. Basophilia, thrombocytosis, and eosinophilia are also common. (B) Aspirate smear. Myeloid hyperplasia without overt granulocytic dysplasia, frequent myelocytes (so-called “myelocyte bulge”) and marrow eosinophilia. Note the micromegakaryocyte or “dwarf megakaryocyte” in the lower left-corner. (C) aCML peripheral blood smear. Frequent dysplastic neutrophils; note the dysplastic morphologic features including hypogranularity and hypolobation (pseudo-Pelger–Huët anomaly, inset). (D) aCML aspirate smear. Myeloid hyperplasia with prominent dysplasia and without basophilia/eosinophilia. (E) CNL peripheral blood smear. Neutrophilia without dysplastic forms or immature granulocytes. (F) CNL Aspirate smear. Myeloid hyperplasia without dysplastic morphologic features or basophilia/eosinophilia. Images obtained at 63×, courtesy of Dr Philipp W. Raess.