MYC-associated pathways in the regulation of proliferation and survival. MYC forms a heterodimer with MAX that activates pathways associated with both cell proliferation and growth and oncogenic stress response. Proliferation is initiated via activation of cell-cycle-associated molecules such as cyclins and cyclin-dependent kinases, among others, and the induction of apoptosis is triggered via up-regulation of BIM and p53. The PI3K-signaling pathway cooperates with MYC in cell proliferation and survival.