Figure 2.
Schematic model of HIF-1α expression. At low oxygen levels, HIF-1α protein is stable, heterodimerizes, and translocates to the nucleus. At higher oxygen levels, HIF-1α is hydroxylated and targeted to the proteasome.
Schematic model of HIF-1α expression. At low oxygen levels, HIF-1α protein is stable, heterodimerizes, and translocates to the nucleus. At higher oxygen levels, HIF-1α is hydroxylated and targeted to the proteasome.
