Figure illustrating the location of mutations resulting in the various VWD subtypes. Types 1 and 3 VWD are caused by different types of mutation throughout the VWF sequence. In contrast, the type 2 VWD mutations are localized to distinct functional domains of VWF, affecting multimer structure (2A), binding to FVIII (2N), platelets (2B and 2M), and collagen (2M).