Table 1.
High-risk factors at diagnosis
Cytogenetics: del(13) is high risk by metaphase karyotyping. Recommend that FISH be performed after CD138 selection of BM cells to increase plasma cell yield. GEP 70 is validated; EMC-92 has early validation and is ongoing. New molecular genetic tests await validation in multiple datasets.
LDH indicates lactate dehydrogenase; EMC, Erasmus Medical Center; and GEP, gene expression profile.
