ASCIE. ASCIE is defined as an area of restricted diffusion on DWI sequences (A) with a corresponding decrease in signal intensity on the apparent diffusivity coefficient (ADC) map (B) in the absence of focal neurologic findings that could be explained by the location of the DWI-positive lesion. The lesion has increased signal on T2 and T2-fluid-attenuated inversion recovery images (data not shown).