Table 1.
Factors prognostic of high-risk disease
* Cardiac failure, renal failure.
† There is a strong association among adverse genetic factors: the cooccurrence of 2 or 3 of them [particularly t(4;14) and del 17p] identifies an ultra-high-risk subset (OS: <2 y). Ultra-high risk can also be defined by the coexistence of adverse cytogenetics, ISS III, and either high lactate dehydrogenase (LDH) or failure to achieve CR (OS: ∼2 y).
