Figure 2.
Identification of a CMML transcriptional signature. (A) Venn diagram illustrating the number of differentially expressed genes in CMML vs old controls (blue) compared with young controls vs old controls (red) using an FDR < 0.01. (B) Unsupervised clustering heat map of the 2480 genes that are unique to the CMML vs old controls set, shown in CMML and normal old and young control monocytes. (C) Heat map of the top 25 most significant genes of the CMML signature. (D) RNAseq and qPCR gene expression normalized values for TEX14, PLK2, CAMKK2, RPA1, and CXCL8 transcripts. P values were calculated using the nonparametric Mann-Whitney U test. **P < 0.01; ****P < 0.0001.

Identification of a CMML transcriptional signature. (A) Venn diagram illustrating the number of differentially expressed genes in CMML vs old controls (blue) compared with young controls vs old controls (red) using an FDR < 0.01. (B) Unsupervised clustering heat map of the 2480 genes that are unique to the CMML vs old controls set, shown in CMML and normal old and young control monocytes. (C) Heat map of the top 25 most significant genes of the CMML signature. (D) RNAseq and qPCR gene expression normalized values for TEX14, PLK2, CAMKK2, RPA1, and CXCL8 transcripts. P values were calculated using the nonparametric Mann-Whitney U test. **P < 0.01; ****P < 0.0001.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal