Significant associations are seen between NMF components and specific genetic lesions. Each NMF component is associated with specific genetic lesions, and these genetic profiles are unique with the exception of SRSF2 mutations associated with components 3 and 4. (A) Patient samples (columns) are plotted in order of their component amplitudes (first row, blue to red) with cluster membership (second row, colored tiles) and presence of specific genetic mutations (black tiles). P values and FDRs based on 100 000 permutations. (B) Example of how components 3 and 4 are associated with genetic lesions even in clusters that are more closely associated with different components. Box plots for component scores are plotted by cluster for patients with and without the specific lesion for the 3 most highly associated lesions. *P < .05; **P < .01. IC, information coefficient; ns, not significant.