Kaplan-Meier survival analysis of mice with various genotypes. The mortality rate (percentage) was determined for 6 months in mice with various genotypes. The log-rank (Mantel-Cox) test was used to compare the difference in the mortality rate between the control group (wt or cfh^W/R) and each of other genotypes. *P < .05, **P < .01, ***P < .005, and ****P < .0001, respectively. a13^−/−, Adamts13^−/−; cfh^W/R and cfh^R/R are the heterozygous and homozygous mutations, respectively.