Oral administration of AV513 to AAV-FVIII hemophilia A dogs accelerates the plasma clotting time. Plasma prepared from AAV-hemophilia A dogs before and at the end of each dosing period were evaluated for clotting in a TEG assay. A TEG R time averaged from 3 dogs after each dose is represented as a bar graph with error bars representing SD. *P = .05, **P = .01 compared with baseline values.